Evaluation of polymyxin B AUC/MIC ratio for dose optimization in patients with carbapenem-resistant Klebsiella pneumoniae infection

Evaluation of polymyxin B AUC/MIC ratio for dose optimization in patients with carbapenem-resistant Klebsiella pneumoniae infection

Polymyxin B has been used as a last-line therapy for the treatment of carbapenem-resistant gram-negative bacterial infection. The pharmacokinetic/pharmacodynamic index (AUC/MIC) of polymyxin B has not been clinically evaluated, given that the broth microdilution method for polymyxin susceptibility t...

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Bibliographic Details
Main Authors: Peile Wang, Shaohua Liu, Guangzhao Qi, Min Xu, Tongwen Sun, Jing Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Microbiology
Subjects:
Carbapenem-resistant Klebsiella pneumonia
polymyxin B
antimicrobial susceptibility testing
AUC/MIC
Monte Carlo simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1226981/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1226981/full

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