Spin-label scanning reveals conformational sensitivity of the bound helical interfaces of IA<sub>3</sub>

Spin-label scanning reveals conformational sensitivity of the bound helical interfaces of IA<sub>3</sub>

IA<sub>3</sub> is an intrinsically disordered protein (IDP) that becomes helical when bound to yeast proteinase A (YPRA) or in the presence of the secondary stabilizer 2,2,2-trifluoroethanol (TFE). Here, site-directed spin-labeling (SDSL) continuous wave electron paramagnetic resonance...

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Bibliographic Details
Main Authors: Katie M. Dunleavy, Eugene Milshteyn, Zachary Sorrentino, Natasha L. Pirman, Zhanglong Liu, Matthew B. Chandler, Peter W. D’Amore, Gail E. Fanucci
Format: Article
Language:English
Published: AIMS Press 2018-09-01
Series:AIMS Biophysics
Subjects:
site-directed spin-labeling
intrinsically disordered protein
IA<sub>3</sub>
nitroxide label
electron paramagnetic resonance
circular dichroism
Online Access:http://www.aimspress.com/biophysics/article/3103/fulltext.html

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http://www.aimspress.com/biophysics/article/3103/fulltext.html

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