Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer’s disease

Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer’s disease

IntroductionDysfunction of the cerebral vasculature is considered one of the key components of Alzheimer’s disease (AD), but the mechanisms affecting individual brain vessels are poorly understood.MethodsHere, using in vivo two-photon microscopy in superficial cortical layers and ex vivo imaging acr...

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Bibliographic Details
Main Authors: Oleg Zhukov, Chen He, Rana Soylu-Kucharz, Changsi Cai, Andreas D. Lauritzen, Blanca Irene Aldana, Maria Björkqvist, Martin Lauritzen, Krzysztof Kucharz
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
5xFAD
two-photon microscopy
blood-brain barrier
adsorptive-mediated transcytosis
neurovascular coupling
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1089005/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1089005/full

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