Genetic diversity of transmission-blocking vaccine candidate Pvs48/45 in Plasmodium vivax populations in China

Genetic diversity of transmission-blocking vaccine candidate Pvs48/45 in Plasmodium vivax populations in China

Abstract Background The male gamete fertilization factor P48/45 in malaria parasites is a prime transmission-blocking vaccine (TBV) candidate. Efforts to develop antimalarial vaccines are often thwarted by genetic diversity of the target antigens. Here we evaluated the genetic diversity of Pvs48/45...

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Bibliographic Details
Main Authors: Hui Feng, Bhavna Gupta, Meilian Wang, Wenqi Zheng, Li Zheng, Xiaotong Zhu, Yimei Yang, Qiang Fang, Enjie Luo, Qi Fan, Takafumi Tsuboi, Yaming Cao, Liwang Cui
Format: Article
Language:English
Published: BMC 2015-12-01
Series:Parasites & Vectors
Subjects:
Plasmodium vivax
Transmission blocking vaccine
pvs48/45
Genetic polymorphism
Positive selection
Online Access:https://doi.org/10.1186/s13071-015-1232-4

Internet

https://doi.org/10.1186/s13071-015-1232-4

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