Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart

Integrated Multilayer Omics Reveals the Genomic, Proteomic, and Metabolic Influences of Histidyl Dipeptides on the Heart

Background Histidyl dipeptides such as carnosine are present in a micromolar to millimolar range in mammalian hearts. These dipeptides facilitate glycolysis by proton buffering. They form conjugates with reactive aldehydes, such as acrolein, and attenuate myocardial ischemia–reperfusion injury. Alth...

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Bibliographic Details
Main Authors: Keqiang Yan, Zhanlong Mei, Jingjing Zhao, Md Aminul Islam Prodhan, Detlef Obal, Kartik Katragadda, Benjamin Doelling, David Hoetker, Dheeraj Kumar Posa, Liqing He, Xinmin Yin, Jasmit Shah, Jianmin Pan, Shesh Rai, Pawel Konrad Lorkiewicz, Xiang Zhang, Siqi Liu, Aruni Bhatnagar, Shahid P. Baba
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
genomics
heart
histidyl dipeptides
metabolomics
proteomics
transcriptomics
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.023868

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.023868

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