Membrane interactions of apoptotic inhibitor Bcl-xL: What can be learned using fluorescence spectroscopy

Permeabilization of the mitochondrial outer membrane–a point of no return in apoptotic regulation–is tightly controlled by proteins of the Bcl-2 family. Apoptotic inhibitor Bcl-xL is an important member of this family, responsible for blocking the permeabilization, and is also a promising target for...

Full description

Bibliographic Details
Main Authors: Alexander Kyrychenko, Alexey S. Ladokhin
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:BBA Advances
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667160323000054