Anlotinib Reverses Multidrug Resistance (MDR) in Osteosarcoma by Inhibiting P-Glycoprotein (PGP1) Function In Vitro and In Vivo
Overexpression of the multidrug resistance (MDR)-related protein P-glycoprotein (PGP1), which actively extrudes chemotherapeutic agents from cells and significantly decreases the efficacy of chemotherapy, is viewed as a major obstacle in osteosarcoma chemotherapy. Anlotinib, a novel tyrosine kinase...
Autori principali: | , , , , , , , , , , , , |
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Natura: | Articolo |
Lingua: | English |
Pubblicazione: |
Frontiers Media S.A.
2022-01-01
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Serie: | Frontiers in Pharmacology |
Soggetti: | |
Accesso online: | https://www.frontiersin.org/articles/10.3389/fphar.2021.798837/full |