The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi
BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might imp...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2018-10-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100301&lng=en&tlng=en |
| _version_ | 1797757277381328896 |
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| author | Aline Luciano Horta Vivian Paulino Figueiredo Ana Luisa Junqueira Leite Guilherme de Paula Costa Ana Paula de Jesus Menezes Camila de Oliveira Ramos Tamiles Caroline Fernandes Pedrosa Frank Silva Bezerra Paula Melo de Abreu Vieira André Talvani |
| author_facet | Aline Luciano Horta Vivian Paulino Figueiredo Ana Luisa Junqueira Leite Guilherme de Paula Costa Ana Paula de Jesus Menezes Camila de Oliveira Ramos Tamiles Caroline Fernandes Pedrosa Frank Silva Bezerra Paula Melo de Abreu Vieira André Talvani |
| author_sort | Aline Luciano Horta |
| collection | DOAJ |
| description | BACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host. |
| first_indexed | 2024-03-12T18:13:35Z |
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| id | doaj.art-b3ffedc7f32e43d28e67fb972c87c29c |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:13:35Z |
| publishDate | 2018-10-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-b3ffedc7f32e43d28e67fb972c87c29c2023-08-02T09:14:12ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602018-10-011131110.1590/0074-02760180271S0074-02762018001100301The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruziAline Luciano HortaVivian Paulino FigueiredoAna Luisa Junqueira LeiteGuilherme de Paula CostaAna Paula de Jesus MenezesCamila de Oliveira RamosTamiles Caroline Fernandes PedrosaFrank Silva BezerraPaula Melo de Abreu VieiraAndré TalvaniBACKGROUND The infection led by Trypanosoma cruzi persists in mammalian tissues causing an inflammatory imbalance. Carvedilol (Cv), a non-selective beta blocker drug indicated to treat heart failure and antihypertensive has shown to promote antioxidant and immunomodulatory properties which might improve the inflammation induced by T. cruzi. OBJECTIVES Evaluate the role of Cv on the inflammatory response of C57BL/6 mice acutely infected with the Colombian strain of T. cruzi. METHODS Animals were infected with the Colombian strain of T. cruzi and treated with Cv (25 mg/kg/day), benznidazole (Bz) (100 mg/kg/day) or their combination. On the 28th day of infection and 23 days of treatment, the euthanasia occurred, and the heart preserved for histopathological, oxidative stress (SOD, catalase, TBARs, carbonylated proteins) and plasma (CCL2, CCL5, TNF, IL-10) analyses. Parasitaemia and survival were assessed along the infection. FINDINGS Cv decreased TBARs, but increased the mortality rate, the parasitaemia and the levels of CCL2, CCL5, catalase and the inflammatory infiltrate in the cardiac tissue. Bz led the reduction of the inflammatory infiltrate and circulating levels of oxidative stress and inflammatory mediators in the infected mice. MAIN CONCLUSIONS Our data suggest that Cv, in this experimental model using the Colombian strain of T. cruzi, caused damage to the host.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100301&lng=en&tlng=encarvedilolTrypanosoma cruziinflammationheart diseasechemokines |
| spellingShingle | Aline Luciano Horta Vivian Paulino Figueiredo Ana Luisa Junqueira Leite Guilherme de Paula Costa Ana Paula de Jesus Menezes Camila de Oliveira Ramos Tamiles Caroline Fernandes Pedrosa Frank Silva Bezerra Paula Melo de Abreu Vieira André Talvani The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi Memorias do Instituto Oswaldo Cruz carvedilol Trypanosoma cruzi inflammation heart disease chemokines |
| title | The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi |
| title_full | The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi |
| title_fullStr | The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi |
| title_full_unstemmed | The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi |
| title_short | The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi |
| title_sort | β blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by colombian strain of the trypanosoma cruzi |
| topic | carvedilol Trypanosoma cruzi inflammation heart disease chemokines |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018001100301&lng=en&tlng=en |
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