PhICl2-Mediated Regioselective and Electrophilic Oxythio/Selenocyanation of o-(1-Alkynyl)benzoates: Access to Biologically Active S/SeCN-Containing Isocoumarins

PhICl2-Mediated Regioselective and Electrophilic Oxythio/Selenocyanation of o-(1-Alkynyl)benzoates: Access to Biologically Active S/SeCN-Containing Isocoumarins

The application of PhICl2/NH4SCN and PhICl2/KSeCN reagent systems to the synthesis of the biologically active S/SeCN-containing isocoumarins via a process involving thio/selenocyanation, enabled by thio/selenocyanogen chloride generated in situ, followed with an intramolecular lactonization was real...

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Bibliographic Details
Main Authors: Shanqing Tao, Aiwen Huo, Yan Gao, Xiangyang Zhang, Jingyue Yang, Yunfei Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Chemistry
Subjects:
PhICl2
oxythiocyanation
oxyselenocyanation
o-(1-Alkynyl)benzoate
isocoumarin
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.859995/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.859995/full

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