Assessment of DNA interstrand crosslinks in NIH/3T3 cells induced by Chloroethylnitrosoureas

Aim: To investigated the mechanism of Chloroethylnitrosoureas (CENUs) leading to secondary tumors after therapy, three kinds of CENUs, namely, Nimustine (ACNU), Carmustine (BCNU) and Semustine (MeCCNU) were used to investigated drug-induced DNA interstrand crosslinks(ICLs). Method: The alkaline come...

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Bibliographic Details
Main Authors: Zheng Xiaotong, Chen Xuechai, Zhao Linna, Guo Minjun, Zhong Rugang
Format: Article
Language:English
Published: EDP Sciences 2017-01-01
Series:BIO Web of Conferences
Online Access:http://dx.doi.org/10.1051/bioconf/20170801019