RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanism

RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanism

Angioimmunoblastic T-cell lymphoma (AITL) is a malignant hematologic tumor arising from T follicular helper (Tfh) cells. High-throughput genomic sequencing studies have shown that AITL is characterized by a novel highly recurring somatic mutation in RHOA, encoding p.Gly17Val (RHOA G17V). However, th...

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Bibliographic Details
Main Authors: Fenglian Que, Lihong Zhang, Taoli Wang, Meifang Xu, Wangen Li, Shengbing Zang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
AITL
PON2
RHOA
mutation
NF-κB pathway
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2134536

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2022.2134536

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