The Evidence That 25(OH)D3 and VK2 MK-7 Vitamins Influence the Proliferative Potential and Gene Expression Profiles of Multiple Myeloma Cells and the Development of Resistance to Bortezomib

The Evidence That 25(OH)D3 and VK2 MK-7 Vitamins Influence the Proliferative Potential and Gene Expression Profiles of Multiple Myeloma Cells and the Development of Resistance to Bortezomib

Multiple myeloma (MM) remains an incurable hematological malignancy. Bortezomib (BTZ) is a proteasome inhibitor widely used in MM therapy whose potent activity is often hampered by the development of resistance. The immune system is vital in the pathophysiology of BTZ resistance. Vitamins D (VD) and...

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Bibliographic Details
Main Authors: Karolina Łuczkowska, Piotr Kulig, Bartłomiej Baumert, Bogusław Machaliński
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Nutrients
Subjects:
multiple myeloma
vitamin D
25(OH)D3
vitamin K
VK2 MK-7
resistance to bortezomib
Online Access:https://www.mdpi.com/2072-6643/14/23/5190

Internet

https://www.mdpi.com/2072-6643/14/23/5190

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