Boosting immunotherapy efficacy: Empowering the Potency of Dendritic cells loaded with breast cancer lysates through CTLA-4 suppression

Boosting immunotherapy efficacy: Empowering the Potency of Dendritic cells loaded with breast cancer lysates through CTLA-4 suppression

Anticancer immunotherapies with a dendritic Cell (DC) basis are becoming more popular. However, it has been suggested that the tumor's immunosuppressive mechanisms, such as inhibitory immunological checkpoint molecules, reduce the effectiveness of anticancer immunogenicity mediated by DC. Thus,...

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Bibliographic Details
Main Authors: Mohammad Bakhshivand, Javad Masoumi, Farid Ghorbaninezhad, Leili Aghebati-Maleki, Dariush Shanebandi, Siamak Sandoghchian Shotorbani, Farhad Jadidi-Niaragh, Amir Baghbanzadeh, Nima Hemmat, Elham Baghbani, Amir Ghaffari, Behzad Baradaran
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Heliyon
Subjects:
Dendritic cell
Immune checkponits
CTLA-4
Breast cancer
SiRNA
Cancer immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024137309

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http://www.sciencedirect.com/science/article/pii/S2405844024137309

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