KRAS4A and KRAS4B in liquid biopsy of metastatic lung adenocarcinoma patients treated with Pembrolizumab or chemotherapy plus Pembrolizumab

Abstract KRAS is involved in the stability and expression of PD-L1. We investigated the expression of circulating mRNA (cmRNA) of KRAS4A and KRAS4B and the possible impact on progression-free survival (PFS) of patients with metastatic lung adenocarcinoma treated with immunotherapy. Patients without...

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Bibliographic Details
Main Authors: Rita Chiari, Silvia Palladino, Rita Emili, Mariagrazia De Lisa, Donatella Sarti, Vincenzo Catalano, Mauro Magnani, Francesco Graziano, Annamaria Ruzzo
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48304-0