Oocyte-specific deletion of Pten in mice reveals a stage-specific function of PTEN/PI3K signaling in oocytes in controlling follicular activation.

Oocyte-specific deletion of Pten in mice reveals a stage-specific function of PTEN/PI3K signaling in oocytes in controlling follicular activation.

Immature ovarian primordial follicles are essential for maintenance of the reproductive lifespan of female mammals. Recently, it was found that overactivation of the phosphatidylinositol 3-kinase (PI3K) signaling in oocytes of primordial follicles by an oocyte-specific deletion of Pten (phosphatase...

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Bibliographic Details
Main Authors: Krishna Jagarlamudi, Lian Liu, Deepak Adhikari, Pradeep Reddy, Annika Idahl, Ulrika Ottander, Eva Lundin, Kui Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2702689?pdf=render

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http://europepmc.org/articles/PMC2702689?pdf=render

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