Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension

Pharmacological inhibition of endoplasmic reticulum stress mitigates osteoporosis in a mouse model of hindlimb suspension

Abstract Hindlimb suspension (HLS) mice exhibit osteoporosis of the hindlimb bones and may be an excellent model to test pharmacological interventions. We investigated the effects of inhibiting endoplasmic reticulum (ER) stress with 4-phenyl butyrate (4-PBA) on the morphology, physicochemical proper...

Full description

Bibliographic Details
Main Authors: Hiba Al-Daghestani, Rizwan Qaisar, Sausan Al Kawas, Nurhafizah Ghani, K. G. Aghila Rani, Muhammad Azeem, Hijaz Kamal Hasnan, Nur Karyatee Kassim, A. R. Samsudin
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
4-PBA
ER stress
HLS mice
Osteoporosis
Bone resorption
Online Access:https://doi.org/10.1038/s41598-024-54944-7

Internet

https://doi.org/10.1038/s41598-024-54944-7

Similar Items