Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a

Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a

Normal neurodevelopment requires precise expression of the key ubiquitin ligase gene Ube3a. Comparing newly generated mouse models for Ube3a downregulation (models of Angelman syndrome) vs. Ube3a upregulation (models for autism), we find reciprocal effects of Ube3a gene dosage on phenotypes associat...

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Bibliographic Details
Main Authors: Shu-qun Shi, Carrie E. Mahoney, Pavel Houdek, Wenling Zhao, Matthew P. Anderson, Xinming Zhuo, Arthur Beaudet, Alena Sumova, Thomas E. Scammell, Carl Hirschie Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
circadian
sleep
ubiquitin ligase
neurodevelopmental disorders
Angelman syndrome
UBE3A (E6AP)
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.837523/full

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https://www.frontiersin.org/articles/10.3389/fnbeh.2022.837523/full

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