Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein

Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein

Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are characterized by the aberrant accumulation of intracytoplasmic misfolded and aggregated α-synuclein (α-Syn), resulting in neurodegeneration associated with inflammation. The propagation of α-Syn aggregates from cell to cell is implicat...

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Bibliographic Details
Main Authors: Karen Zagorski, Gor Chailyan, Armine Hovakimyan, Tatevik Antonyan, Sepideh Kiani Shabestari, Irina Petrushina, Hayk Davtyan, David H. Cribbs, Mathew Blurton-Jones, Eliezer Masliah, Michael G. Agadjanyan, Anahit Ghochikyan
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
Alzheimer’s disease
MultiTEP platform
DNA and protein MultiTEP-based vaccines
immunogenicity
anti-α-synuclein antibodies
Online Access:https://www.mdpi.com/1422-0067/23/11/6080

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https://www.mdpi.com/1422-0067/23/11/6080

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