Paeoniflorin Inhibits EMT and Angiogenesis in Human Glioblastoma via K63-Linked C-Met Polyubiquitination-Dependent Autophagic Degradation

Paeoniflorin Inhibits EMT and Angiogenesis in Human Glioblastoma via K63-Linked C-Met Polyubiquitination-Dependent Autophagic Degradation

Epithelial-to-mesenchymal transition (EMT) and angiogenesis have emerged as two pivotal events in cancer progression. Paeoniflorin has been widely studied in experimental models and clinical trials for cancer treatment because of its anti-cancer property. However, the underlying mechanisms of paeoni...

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Bibliographic Details
Main Authors: Zhi Liu, Zhaotao Wang, Danmin Chen, Xiaorui Liu, Guoyong Yu, Yan Zhang, Chen Chen, Ruxiang Xu, Yezhong Wang, Ru-en Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
paeoniflorin
glioblastoma
c-Met
EMT
angiogenesis
polyubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.785345/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.785345/full

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