Superior cuproptotic efficacy of diethyldithiocarbamate-Cu4O3 nanoparticles over diethyldithiocarbamate-Cu2O nanoparticles in metastatic hepatocellular carcinoma

Superior cuproptotic efficacy of diethyldithiocarbamate-Cu4O3 nanoparticles over diethyldithiocarbamate-Cu2O nanoparticles in metastatic hepatocellular carcinoma

Metastatic hepatocellular carcinoma (HC) is a serious health concern. The stemness of cancer stem cells (CSCs) is a key driver for HC tumorigenesis, apoptotic resistance, and metastasis, and functional mitochondria are critical for its maintenance. Cuproptosis is Cu-dependent non-apoptotic pathway (...

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Bibliografische gegevens
Hoofdauteurs: Marwa M. Abu-Serie, Assem Barakat, Sherif Ramadan, Noha Hassan Habashy
Formaat: Artikel
Taal:English
Gepubliceerd in: Frontiers Media S.A. 2024-07-01
Reeks:Frontiers in Pharmacology
Onderwerpen:
metastatic liver cancer
diethyldithiocarbamate-Cu4O3 nanocomplex (DC(I+II)NPs)
diethyldithiocarbamate-Cu2O nanocomplex (DC(I)NPs)
stemness genes
cuproptosis induction
oxidant activity
Online toegang:https://www.frontiersin.org/articles/10.3389/fphar.2024.1388038/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1388038/full

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