Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

Chemotherapy weakly contributes to predicted neoantigen expression in ovarian cancer

Abstract Background Patients with highly mutated tumors, such as melanoma or smoking-related lung cancer, have higher rates of response to immune checkpoint blockade therapy, perhaps due to increased neoantigen expression. Many chemotherapies including platinum compounds are known to be mutagenic, b...

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Bibliographic Details
Main Authors: Timothy O’Donnell, Elizabeth L. Christie, Arun Ahuja, Jacqueline Buros, B. Arman Aksoy, David D. L. Bowtell, Alexandra Snyder, Jeff Hammerbacher
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Cancer
Subjects:
Neoantigen
Mutational signature
Chemotherapy
Online Access:http://link.springer.com/article/10.1186/s12885-017-3825-0

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http://link.springer.com/article/10.1186/s12885-017-3825-0

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