Proinflammatory and immunoregulatory role of eicosanoids in T cells
Eicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane phospholipids by phospholipase A2 to ω-3 and ω-6 C-20 fatty acids that next are converted to leukotrienes (LTs), prostaglandins (PGs), prostacyclins (PCs) and thromboxanes (TXAs). The rate-limiting and tightly regul...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-06-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00130/full |
| _version_ | 1819262359740350464 |
|---|---|
| author | Anna Mari Lone Anna Mari Lone Anna Mari Lone Kjetil eTaskén Kjetil eTaskén Kjetil eTaskén Kjetil eTaskén |
| author_facet | Anna Mari Lone Anna Mari Lone Anna Mari Lone Kjetil eTaskén Kjetil eTaskén Kjetil eTaskén Kjetil eTaskén |
| author_sort | Anna Mari Lone |
| collection | DOAJ |
| description | Eicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane phospholipids by phospholipase A2 to ω-3 and ω-6 C-20 fatty acids that next are converted to leukotrienes (LTs), prostaglandins (PGs), prostacyclins (PCs) and thromboxanes (TXAs). The rate-limiting and tightly regulated lipoxygenases control synthesis of LTs while the equally well-controlled cyclooxygenases 1 and 2 generate prostanoids, including PGs, PCs and TXAs. While many of the classical signs of inflammation such as redness, swelling, pain and heat are caused by eicosanoid species with vasoactive, pyretic and pain-inducing effects locally, some eicosanoids also regulate T cell functions. Here, we will review eicosanoid production in T cell subsets and the inflammatory and immunoregulatory functions of LTs, PGs, PCs and TXAs in T cells. |
| first_indexed | 2024-12-23T19:56:27Z |
| format | Article |
| id | doaj.art-b42570025d41400480a761ea3f7e7b41 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T19:56:27Z |
| publishDate | 2013-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b42570025d41400480a761ea3f7e7b412022-12-21T17:33:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-06-01410.3389/fimmu.2013.0013053482Proinflammatory and immunoregulatory role of eicosanoids in T cellsAnna Mari Lone0Anna Mari Lone1Anna Mari Lone2Kjetil eTaskén3Kjetil eTaskén4Kjetil eTaskén5Kjetil eTaskén6University of Oslo and Oslo University HospitalUniversity of OsloUniversity of OsloUniversity of Oslo and Oslo University HospitalUniversity of OsloUniversity of OsloOslo University HospitalEicosanoids are inflammatory mediators primarily generated by hydrolysis of membrane phospholipids by phospholipase A2 to ω-3 and ω-6 C-20 fatty acids that next are converted to leukotrienes (LTs), prostaglandins (PGs), prostacyclins (PCs) and thromboxanes (TXAs). The rate-limiting and tightly regulated lipoxygenases control synthesis of LTs while the equally well-controlled cyclooxygenases 1 and 2 generate prostanoids, including PGs, PCs and TXAs. While many of the classical signs of inflammation such as redness, swelling, pain and heat are caused by eicosanoid species with vasoactive, pyretic and pain-inducing effects locally, some eicosanoids also regulate T cell functions. Here, we will review eicosanoid production in T cell subsets and the inflammatory and immunoregulatory functions of LTs, PGs, PCs and TXAs in T cells.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00130/fullCyclooxygenase 2InflammationInflammation MediatorsLeukotrienesProstaglandinsT cells |
| spellingShingle | Anna Mari Lone Anna Mari Lone Anna Mari Lone Kjetil eTaskén Kjetil eTaskén Kjetil eTaskén Kjetil eTaskén Proinflammatory and immunoregulatory role of eicosanoids in T cells Frontiers in Immunology Cyclooxygenase 2 Inflammation Inflammation Mediators Leukotrienes Prostaglandins T cells |
| title | Proinflammatory and immunoregulatory role of eicosanoids in T cells |
| title_full | Proinflammatory and immunoregulatory role of eicosanoids in T cells |
| title_fullStr | Proinflammatory and immunoregulatory role of eicosanoids in T cells |
| title_full_unstemmed | Proinflammatory and immunoregulatory role of eicosanoids in T cells |
| title_short | Proinflammatory and immunoregulatory role of eicosanoids in T cells |
| title_sort | proinflammatory and immunoregulatory role of eicosanoids in t cells |
| topic | Cyclooxygenase 2 Inflammation Inflammation Mediators Leukotrienes Prostaglandins T cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00130/full |
| work_keys_str_mv | AT annamarilone proinflammatoryandimmunoregulatoryroleofeicosanoidsintcells AT annamarilone proinflammatoryandimmunoregulatoryroleofeicosanoidsintcells AT annamarilone proinflammatoryandimmunoregulatoryroleofeicosanoidsintcells AT kjetiletasken proinflammatoryandimmunoregulatoryroleofeicosanoidsintcells AT kjetiletasken proinflammatoryandimmunoregulatoryroleofeicosanoidsintcells AT kjetiletasken proinflammatoryandimmunoregulatoryroleofeicosanoidsintcells AT kjetiletasken proinflammatoryandimmunoregulatoryroleofeicosanoidsintcells |