Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases

Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease, are a class of diseases that lead to dysfunction of cognition and mobility. Aggregates of misfolded proteins such as β-amyloid, tau, α-synuclein, and polyglutamates are known to be among the mai...

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Bibliographic Details
Main Authors: Soonsil Hyun, Dongyun Shin
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/11/7/607