Trametinib-Resistant Melanoma Cells Displaying MITF<sup>high</sup>/NGFR<sup>low</sup>/IL-8<sup>low</sup> Phenotype Are Highly Responsive to Alternating Periods of Drug Withdrawal and Drug Rechallenge

Trametinib-Resistant Melanoma Cells Displaying MITF<sup>high</sup>/NGFR<sup>low</sup>/IL-8<sup>low</sup> Phenotype Are Highly Responsive to Alternating Periods of Drug Withdrawal and Drug Rechallenge

Despite significant advances in targeted therapies against the hyperactivated BRAF<sup>V600</sup>/MEK pathway for patients with unresectable metastatic melanoma, acquired resistance remains an unsolved clinical problem. In this study, we focused on melanoma cells resistant to trametinib,...

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Bibliographic Details
Main Authors: Paulina Koziej, Katarzyna Kluszczynska, Mariusz L. Hartman, Malgorzata Czyz
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
cancer cell plasticity
drug holiday
drug rechallenge
IL-8
MITF
melanoma
Online Access:https://www.mdpi.com/1422-0067/24/9/7891

Internet

https://www.mdpi.com/1422-0067/24/9/7891

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