Microbe-derived uremic solutes enhance thrombosis potential in the host

Microbe-derived uremic solutes enhance thrombosis potential in the host

ABSTRACTp-Cresol sulfate (pCS) and indoxyl sulfate (IS), gut microbiome-derived metabolites, are traditionally associated with cardiovascular disease (CVD) risks in the setting of impaired kidney function. While pharmacologic provision of pCS or IS can promote pro-thrombotic phenotypes, neither the...

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Bibliographic Details
Main Authors: Ina Nemet, Masanori Funabashi, Xinmin S. Li, Mohammed Dwidar, Naseer Sangwan, Sarah M. Skye, Kymberleigh A. Romano, Tomas Cajka, Brittany D. Needham, Sarkis K. Mazmanian, Adeline M. Hajjar, Federico E. Rey, Oliver Fiehn, W. H. Wilson Tang, Michael A. Fischbach, Stanley L. Hazen
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
gut microbes
uremic toxins
p-cresol sulfate
indoxyl sulfate
cardiovascular disease
mortality
Online Access:https://journals.asm.org/doi/10.1128/mbio.01331-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01331-23

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