Mitochondria-originated redox signalling regulates KLF-1 to promote longevity in Caenorhabditis elegans

Alternations of redox metabolism have been associated with the extension of lifespan in roundworm Caenorhabditis elegans, caused by moderate mitochondrial dysfunction, although the underlying signalling cascades are largely unknown. Previously, we identified transcriptional factor Krüppel-like facto...

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Bibliographic Details
Main Authors: Johannes CW Hermeling, Marija Herholz, Linda Baumann, Estela Cepeda Cores, Aleksandra Zečić, Thorsten Hoppe, Jan Riemer, Aleksandra Trifunovic
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003056