Preparation of Hot-Melt-Extruded Solid Dispersion Based on Pre-Formulation Strategies and Its Enhanced Therapeutic Efficacy

Preparation of Hot-Melt-Extruded Solid Dispersion Based on Pre-Formulation Strategies and Its Enhanced Therapeutic Efficacy

In this study, an amorphous solid dispersion containing the poorly water-soluble drug, bisacodyl, was prepared by hot-melt extrusion to enhance its therapeutic efficacy. First, the miscibility and interaction between the drug and polymer were investigated as pre-formulation strategies using various...

Full description

Bibliographic Details
Main Authors: Seon-Kwang Lee, Eun-Sol Ha, Heejun Park, Kyu-Tae Kang, Ji-Su Jeong, Jeong-Soo Kim, In-hwan Baek, Min-Soo Kim
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceutics
Subjects:
hot-melt extrusion
solid dispersion
miscibility
molecular interaction
bisacodyl
in vivo efficacy
Online Access:https://www.mdpi.com/1999-4923/15/12/2704

Internet

https://www.mdpi.com/1999-4923/15/12/2704

Similar Items