Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD): A Pharmacokinetics Study on Rats

Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD): A Pharmacokinetics Study on Rats

The study aims to investigate the ability of lyophilized nasal inserts of nanosized atomoxetine HCl solid lipid nanoparticles (ATM-SLNs) to transport atomoxetine (ATM) directly to the brain and overcome the first-pass metabolism. In this case, 16 formulae of (ATM-SLNs) were prepared using hot melt e...

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Bibliographic Details
Main Authors: Mahmoud H. Teaima, Merhan Taha El-Nadi, Raghda Rabe Hamed, Mohamed A. El-Nabarawi, Rehab Abdelmonem
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
ADHD
atomoxetine HCl
brain targeting
solid lipid nanoparticles (SLNs)
nasal inserts
Online Access:https://www.mdpi.com/1424-8247/16/2/326

Internet

https://www.mdpi.com/1424-8247/16/2/326

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