DNA 5-methylcytosine detection and methylation phasing using PacBio circular consensus sequencing

DNA 5-methylcytosine detection and methylation phasing using PacBio circular consensus sequencing

Abstract Long single-molecular sequencing technologies, such as PacBio circular consensus sequencing (CCS) and nanopore sequencing, are advantageous in detecting DNA 5-methylcytosine in CpGs (5mCpGs), especially in repetitive genomic regions. However, existing methods for detecting 5mCpGs using PacB...

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Bibliographic Details
Main Authors: Peng Ni, Fan Nie, Zeyu Zhong, Jinrui Xu, Neng Huang, Jun Zhang, Haochen Zhao, You Zou, Yuanfeng Huang, Jinchen Li, Chuan-Le Xiao, Feng Luo, Jianxin Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39784-9

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https://doi.org/10.1038/s41467-023-39784-9

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