Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles

Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles

Adeno-associated virus (AAV)-mediated gene transfer is an efficient method of gene over-expression in the vestibular end organs. However, AAV has limited usefulness for delivering a large gene, or multiple genes, due to its small packaging capacity (< 5 kb). Co-transduction of dual-AAV vector...

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Bibliographic Details
Main Authors: Zhong-Rui Chen, Jing-Ying Guo, Lu He, Shan Liu, Jun-Yi Xu, Zi-Jing Yang, Wei Su, Ke Liu, Shu-Sheng Gong, Guo-Peng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
adeno-associated virus
gene transfer
utricle
mice
hair cell
transduction
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1020803/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.1020803/full

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