Antiviral Targeting of Varicella Zoster Virus Replication and Neuronal Reactivation Using CRISPR/Cas9 Cleavage of the Duplicated Open Reading Frames 62/71

Antiviral Targeting of Varicella Zoster Virus Replication and Neuronal Reactivation Using CRISPR/Cas9 Cleavage of the Duplicated Open Reading Frames 62/71

Varicella Zoster Virus (VZV) causes Herpes Zoster (HZ), a common debilitating and complicated disease affecting up to a third of unvaccinated populations. Novel antiviral treatments for VZV reactivation and HZ are still in need. Here, we evaluated the potential of targeting the replicating and react...

Full description

Bibliographic Details
Main Authors: Betty W. Wu, Michael B. Yee, Ronald S. Goldstein, Paul R. Kinchington
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Viruses
Subjects:
varicella zoster virus
latency
reactivation
genome cleavage
CRISPR/Cas9
AAV
Online Access:https://www.mdpi.com/1999-4915/14/2/378

Internet

https://www.mdpi.com/1999-4915/14/2/378

Similar Items