<i>In Vivo</i> Expression of Reprogramming Factor OCT4 Ameliorates Myelination Deficits and Induces Striatal Neuroprotection in Huntington’s Disease

<i>In Vivo</i> Expression of Reprogramming Factor OCT4 Ameliorates Myelination Deficits and Induces Striatal Neuroprotection in Huntington’s Disease

White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington’s disease (HD). This study investigated the effects of <i>in vivo</i> expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) nic...

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Bibliographic Details
Main Authors: Ji-Hea Yu, Bae-Geun Nam, Min-Gi Kim, Soonil Pyo, Jung-Hwa Seo, Sung-Rae Cho
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Genes
Subjects:
Huntington’s disease
reprogramming
octamer-binding transcription factor 4
oligodendrocyte progenitor cells
Online Access:https://www.mdpi.com/2073-4425/12/5/712

Internet

https://www.mdpi.com/2073-4425/12/5/712

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