<i>In Vivo</i> Expression of Reprogramming Factor OCT4 Ameliorates Myelination Deficits and Induces Striatal Neuroprotection in Huntington’s Disease

<i>In Vivo</i> Expression of Reprogramming Factor OCT4 Ameliorates Myelination Deficits and Induces Striatal Neuroprotection in Huntington’s Disease

White matter atrophy has been shown to precede the massive loss of striatal GABAergic neurons in Huntington’s disease (HD). This study investigated the effects of <i>in vivo</i> expression of reprogramming factor octamer-binding transcription factor 4 (OCT4) on neural stem cell (NSC) nic...

Full description

Bibliographic Details
Main Authors:	Ji-Hea Yu, Bae-Geun Nam, Min-Gi Kim, Soonil Pyo, Jung-Hwa Seo, Sung-Rae Cho
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	Genes
Subjects:	Huntington’s disease reprogramming octamer-binding transcription factor 4 oligodendrocyte progenitor cells
Online Access:	https://www.mdpi.com/2073-4425/12/5/712

Similar Items

Manipulation of microbiota reveals altered callosal myelination and white matter plasticity in a model of Huntington disease
by: Carola I. Radulescu, et al.
Published: (2019-07-01)

Cell Reprogramming to Model Huntington’s Disease: A Comprehensive Review
by: Ruth Monk, et al.
Published: (2021-06-01)

Striatal Vulnerability in Huntington’s Disease: Neuroprotection Versus Neurotoxicity
by: Ryoma Morigaki, et al.
Published: (2017-06-01)

Oligodendroglial Energy Metabolism and (re)Myelination
by: Vanja Tepavčević
Published: (2021-03-01)

Mutant HTT does not affect glial development but impairs myelination in the early disease stage
by: Sitong Yang, et al.
Published: (2023-07-01)

Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination
by: Mathilde Pruvost, et al.
Published: (2021-01-01)

In Vivo Reprogramming Using Yamanaka Factors in the CNS: A Scoping Review
by: Han Eol Cho, et al.
Published: (2024-02-01)

Chronic Exposure to Alcohol Inhibits New Myelin Generation in Adult Mouse Brain
by: Feng Guo, et al.
Published: (2021-08-01)

PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination
by: Yan Wang, et al.
Published: (2021-10-01)

How big is the myelinating orchestra? Cellular diversity within the oligodendrocyte lineage: facts and hypotheses.
by: Giulio eSrubek Tomassy, et al.
Published: (2014-07-01)

Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells
by: Davide Marangon, et al.
Published: (2022-08-01)

Insights into White Matter Defect in Huntington’s Disease
by: Yize Sun, et al.
Published: (2022-10-01)

Metabolomics Profile of the Secretome of Space-Flown Oligodendrocytes
by: Laurent Vergnes, et al.
Published: (2023-09-01)

A platform for studies of Huntington’s disease on the basis of induced pluripotent stem cells
by: E. D. Nekrasov, et al.
Published: (2017-02-01)

Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
by: Julia eMargulis, et al.
Published: (2014-08-01)

Non-Cell Autonomous and Epigenetic Mechanisms of Huntington’s Disease
by: Chaebin Kim, et al.
Published: (2021-11-01)

Structure Insights Into Photosystem I Octamer From Cyanobacteria
by: Ming Chen, et al.
Published: (2022-05-01)

3D Imaging of Striatal Transplants in a Small Animal Model of Huntington’s Disease
by: Elisabeth Schültke, et al.
Published: (2023-07-01)

Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages
by: Dominik Michalski, et al.
Published: (2018-02-01)

Purinergic Receptors on Oligodendrocyte Progenitors: Promising Targets for Myelin Repair in Multiple Sclerosis?
by: Davide Lecca, et al.
Published: (2021-01-01)

Genetically modified macrophages accelerate myelin repair
by: Marie‐Stéphane Aigrot, et al.
Published: (2022-08-01)

Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma
by: Karolyny Martins Balbinot, et al.
Published: (2023-01-01)

Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats
by: Orsolya Kántor, et al.
Published: (2006-06-01)

Molecular mechanisms involved in the pathogenesis of Huntington's disease /
by: 506084 Perandones, Claudia, et al.
Published: (c201)

Cortical and Striatal Circuits in Huntington’s Disease
by: Sonja Blumenstock, et al.
Published: (2020-02-01)

Oligodendrogenesis after Cerebral Ischaemia and Traumatic Brain Injury
by: Zheng Gang Zhang, et al.
Published: (2013-08-01)

STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury
by: Amber R. Hackett, et al.
Published: (2016-05-01)

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline
by: Abbe H. Crawford, et al.
Published: (2016-04-01)

Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive Without Neuroprotection in the Spinal Contusion Cavity
by: Zachary T. Olmsted, et al.
Published: (2022-01-01)

Striatal Network Models of Huntington's Disease Dysfunction Phenotypes
by: Pengsheng Zheng, et al.
Published: (2017-07-01)

Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons
by: Yu Tang, et al.
Published: (2017-11-01)

Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers
by: Sujatha eMuralidharan, et al.
Published: (2015-10-01)

BACHD Mice Recapitulate the Striatal Parvalbuminergic Interneuron Loss Found in Huntington’s Disease
by: Vyshnavi Rallapalle, et al.
Published: (2021-05-01)

Huntington’s disease and brain development
by: Humbert, Sandrine, et al.
Published: (2022-10-01)

Targeting the conserved coronavirus octamer motif GGAAGAGC is a strategy for the development of coronavirus vaccine
by: Ching-Hung Lin, et al.
Published: (2023-11-01)

Quantitative determination of linking number differences between circular polynucleosomes and histone H1-bound circular polynucleosomes
by: Zhang, Hao, et al.
Published: (2019)

Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease
by: Carmela Giampà, et al.
Published: (2009-06-01)

Oligodendroglial Heterogeneity in Neuropsychiatric Disease
by: Sunniva M. K. Bøstrand, et al.
Published: (2021-02-01)

Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s disease
by: S. Fernández-García, et al.
Published: (2020-05-01)

Unraveling Myelin Plasticity
by: Giulia Bonetto, et al.
Published: (2020-06-01)