Aging in Rats Differentially Affects Markers of Transcriptional and Translational Capacity in Soleus and Plantaris Muscle

Aging in Rats Differentially Affects Markers of Transcriptional and Translational Capacity in Soleus and Plantaris Muscle

Alterations in transcriptional and translational mechanisms occur during skeletal muscle aging and such changes may contribute to age-related atrophy. Herein, we examined markers related to global transcriptional output (i.e., myonuclear number, total mRNA and RNA pol II levels), translational effic...

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Bibliographic Details
Main Authors: Christopher B. Mobley, Petey W. Mumford, Wesley C. Kephart, Cody T. Haun, Angelia M. Holland, Darren T. Beck, Jeffrey S. Martin, Kaelin C. Young, Richard G. Anderson, Romil K. Patel, Gillis L. Langston, Ryan P. Lowery, Jacob M. Wilson, Michael D. Roberts
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Physiology
Subjects:
fast-twitch muscle
aging
atrophy
muscle protein synthesis
mRNA
ribosome
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00518/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00518/full

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