Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice

Glycolytic inhibitor 2-deoxyglucose simultaneously targets cancer and endothelial cells to suppress neuroblastoma growth in mice

Neuroblastoma is characterized by a wide range of clinical manifestations and associated with poor prognosis when there is amplification of MYCN oncogene or high expression of Myc oncoproteins. In a previous in vitro study, we found that the glycolytic inhibitor 2-deoxyglucose (2DG) could suppress t...

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Bibliographic Details
Main Authors: Chao-Cheng Huang, Shuo-Yu Wang, Li-Ling Lin, Pei-Wen Wang, Ting-Ya Chen, Wen-Ming Hsu, Tsu-Kung Lin, Chia-Wei Liou, Jiin-Haur Chuang
Format: Article
Language:English
Published: The Company of Biologists 2015-10-01
Series:Disease Models & Mechanisms
Subjects:
Neuroblastoma
2-deoxyglucose
Xenograft
MYCN amplification
Endothelial cell
Online Access:http://dmm.biologists.org/content/8/10/1247

Internet

http://dmm.biologists.org/content/8/10/1247

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