Multiomics analysis revealed the mechanisms related to the enhancement of proliferation, metastasis and EGFR-TKI resistance in EGFR-mutant LUAD with ARID1A deficiency

Multiomics analysis revealed the mechanisms related to the enhancement of proliferation, metastasis and EGFR-TKI resistance in EGFR-mutant LUAD with ARID1A deficiency

Abstract Introduction Dysregulated ARID1A expression is frequently detected in lung adenocarcinoma (LUAD) and mediates significant changes in cancer behaviors and a poor prognosis. ARID1A deficiency in LUAD enhances proliferation and metastasis, which could be induced by activation of the Akt signal...

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Bibliographic Details
Main Authors: Dantong Sun, Feiyue Feng, Fei Teng, Tongji Xie, Jinsong Wang, Puyuan Xing, Haili Qian, Junling Li
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cell Communication and Signaling
Subjects:
EGFR-mutant LUAD
EGFR-TKI resistance
ARID1A
Multiomics analysis
Cell cycle
Online Access:https://doi.org/10.1186/s12964-023-01065-9

Internet

https://doi.org/10.1186/s12964-023-01065-9

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