Interaction of oxidative stress and neurotrauma in ALDH2−/− mice causes significant and persistent behavioral and pro-inflammatory effects in a tractable model of mild traumatic brain injury

Interaction of oxidative stress and neurotrauma in ALDH2−/− mice causes significant and persistent behavioral and pro-inflammatory effects in a tractable model of mild traumatic brain injury

Oxidative stress induced by lipid peroxidation products (LPP) accompanies aging and has been hypothesized to exacerbate the secondary cascade in traumatic brain injury (TBI). Increased oxidative stress is a contributor to loss of neural reserve that defines the ability to maintain healthy cognitive...

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Bibliographic Details
Main Authors: Rachel C. Knopp, Sue H. Lee, Michael Hollas, Emily Nepomuceno, David Gonzalez, Kevin Tam, Daniyal Aamir, Yueting Wang, Emily Pierce, Manel BenAissa, Gregory R.J. Thatcher
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Redox Biology
Subjects:
Mild traumatic brain injury
Oxidative stress
Lipid peroxidation
Neuroinflammation
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720300732

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http://www.sciencedirect.com/science/article/pii/S2213231720300732

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