Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

Abstract Drug resistance poses a significant challenge in the development of effective therapies against SARS-CoV-2. Here, we identified two double mutations, M49K/M165V and M49K/S301P, in the 3C-like protease (3CLpro) that confer resistance to a novel non-covalent inhibitor, WU-04, which is current...

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Bibliographic Details
Main Authors: Lijing Zhang, Xuping Xie, Hannan Luo, Runtong Qian, Yang Yang, Hongtao Yu, Jing Huang, Pei-Yong Shi, Qi Hu
Format: Article
Language:English
Published: Nature Publishing Group 2024-04-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00673-0

Internet

https://doi.org/10.1038/s41421-024-00673-0

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