Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04
Abstract Drug resistance poses a significant challenge in the development of effective therapies against SARS-CoV-2. Here, we identified two double mutations, M49K/M165V and M49K/S301P, in the 3C-like protease (3CLpro) that confer resistance to a novel non-covalent inhibitor, WU-04, which is current...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2024-04-01
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Series: | Cell Discovery |
Online Access: | https://doi.org/10.1038/s41421-024-00673-0 |