Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome

Utility of Zebrafish Models of Acquired and Inherited Long QT Syndrome

Long-QT Syndrome (LQTS) is a cardiac electrical disorder, distinguished by irregular heart rates and sudden death. Accounting for ∼40% of cases, LQTS Type 2 (LQTS2), is caused by defects in the Kv11.1 (hERG) potassium channel that is critical for cardiac repolarization. Drug block of hERG channels o...

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Bibliographic Details
Main Authors: Kyle E. Simpson, Ravichandra Venkateshappa, Zhao Kai Pang, Shoaib Faizi, Glen F. Tibbits, Tom W. Claydon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
Long-QT Syndrome
zebrafish
cardiac electrophysiology
inherited LQTS
acquired LQTS
CRISPR
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.624129/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.624129/full

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