Sodium butyrate supresses malignant human mast cell proliferation, downregulates expression of KIT and promotes differentiation

Sodium butyrate supresses malignant human mast cell proliferation, downregulates expression of KIT and promotes differentiation

Sodium butyrate (NaBu) is a class I histone deacetylase inhibitor (HDACi) that can impede the proliferation of transformed cells. Although some HDACi downregulate the expression of the stem cell factor receptor (KIT/CD117), the effect of NaBu on KIT expression and human mast cell proliferation requi...

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Bibliographic Details
Main Authors: Clayton A. MacDonald, Hui Qian, Priyanka Pundir, Marianna Kulka
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Allergy
Subjects:
KIT
histone deacetylase inhibitors
cell cycle
proliferation
viability
Online Access:https://www.frontiersin.org/articles/10.3389/falgy.2023.1109717/full

Internet

https://www.frontiersin.org/articles/10.3389/falgy.2023.1109717/full

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