Rapamycin Improves Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Renoprotective Effect against Cisplatin-Induced Acute Nephrotoxicity in Rats by Inhibiting the mTOR/AKT Signaling Pathway

Rapamycin Improves Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Renoprotective Effect against Cisplatin-Induced Acute Nephrotoxicity in Rats by Inhibiting the mTOR/AKT Signaling Pathway

Objective: Because the poor survival of transplanted cells in a hostile microenvironment limits stem cell therapy, in the current study, we investigated the effect of rapamycin (Rapa)-preactivated autophagy on the survival and homing of transplanted adipose mesenchymal stem cells (ADMSCs) in a rat m...

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Bibliographic Details
Main Authors: Amira Awadalla, Abdelaziz M. Hussein, Yousra M. El-Far, Fardous F. El-Senduny, Nashwa Barakat, Eman T. Hamam, Hanaa M. Abdeen, Mohamed El-Sherbiny, Mohamed S. Serria, Amira A. Sarhan, Asmaa M. Sena, Ahmed A. Shokeir
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
rapamycin
adipose-derived stem cells
cisplatin-nephrotoxicity
autophagy
Online Access:https://www.mdpi.com/2227-9059/10/6/1295

Internet

https://www.mdpi.com/2227-9059/10/6/1295

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