Genomic, transcriptomic and RNA editing analysis of human MM1 and VV2 sporadic Creutzfeldt-Jakob disease

Genomic, transcriptomic and RNA editing analysis of human MM1 and VV2 sporadic Creutzfeldt-Jakob disease

Abstract Creutzfeldt-Jakob disease (CJD) is characterized by a broad phenotypic spectrum regarding symptoms, progression, and molecular features. Current sporadic CJD (sCJD) classification recognizes six main clinical-pathological phenotypes. This work investigates the molecular basis of the phenoty...

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Bibliographic Details
Main Authors: Martina Tarozzi, Simone Baiardi, Claudia Sala, Anna Bartoletti-Stella, Piero Parchi, Sabina Capellari, Gastone Castellani
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Acta Neuropathologica Communications
Subjects:
Prion diseases
Sporadic Creutzfeldt-Jakob disease
NGS
RNA sequencing
Phenotypic heterogeneity
Prion strains
Online Access:https://doi.org/10.1186/s40478-022-01483-9

Internet

https://doi.org/10.1186/s40478-022-01483-9

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