LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes

LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes

Epidemiological studies have shown that abnormalities of glucose metabolism are involved in leucine‐rich repeat kinase 2 (LRRK2)‐associated Parkinson's disease (PD). However, the physiological significance of this association is unclear. In the present study, we investigated the effect of LRRK2...

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Bibliographic Details
Main Authors: Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikawa
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:FEBS Open Bio
Subjects:
adipocyte
glucose tolerance
GLUT4
LRRK2
Rab GTPase
Online Access:https://doi.org/10.1002/2211-5463.13717

Internet

https://doi.org/10.1002/2211-5463.13717

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