Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma

Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma

Abstract Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid, OA) is a kind of pentacyclic triterpene, which widely distributes in nature. OA possesses a powerful anti-cancer effect; however, its low solubility limits its bioavailability and application. In this study, a new OA derivative, K73-03, was...

Full description

Bibliographic Details
Main Authors: Jiaqi Wang, Chuchu Ma, Zhongyuan Tang, Zhengwu Sun, Eskandar Qaed, Xinming Chi, Jun Wang, Yazeed Jamalat, Zhaohong Geng, Zeyao Tang, Qiying Yao
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cancer Cell International
Subjects:
Oleanolic acid derivative
K73-03
Hepatocellular carcinoma
Apoptosis
JAK2/STAT3
NF-κB/P65
Online Access:https://doi.org/10.1186/s12935-023-03119-x

Internet

https://doi.org/10.1186/s12935-023-03119-x

Similar Items