SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

Summary: Intrathecal administration enables central nervous system delivery of drugs that do not bypass the blood-brain barrier. Systemic administration of hypertonic saline (HTS) enhances delivery of intrathecal therapeutics into the neuropil, but its effect on solute clearance from the brain remai...

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Bibliographic Details
Main Authors: Tuomas O. Lilius, Marko Rosenholm, Laura Klinger, Kristian Nygaard Mortensen, Björn Sigurdsson, Frida Lind-Holm Mogensen, Natalie L. Hauglund, Malthe Skytte Nordentoft Nielsen, Tomi Rantamäki, Maiken Nedergaard
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Drug delivery system
Neuroscience
Small animal imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422201522X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422201522X

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