GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells

GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells

Antisense oligonucleotides (ASOs) are short synthetic nucleic acids that recognize and bind to complementary RNA to modulate gene expression. It is well established that single-stranded, phosphorothioate-modified ASOs enter cells independent of carrier molecules, primarily via endocytic pathways, bu...

Full description

Bibliographic Details
Main Authors: Moira A. McMahon, Meghdad Rahdar, Swagatam Mukhopadhyay, Huynh-Hoa Bui, Christopher Hart, Sagar Damle, Margo Courtney, Michael W. Baughn, Don W. Cleveland, C. Frank Bennett
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
antisense oligonucleotide
ASO
CRISPR-Cas
gene activation
GOLGA8
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000768

Internet

http://www.sciencedirect.com/science/article/pii/S2162253123000768

Similar Items