Elevated mRNA-levels of gonadotropin-releasing hormone and its receptor in plaque-bearing Alzheimer's disease transgenic mice.

Research on Alzheimer's disease (AD) has indicated an association between hormones of the hypothalamic-pituitary-gonadal (HPG) axis and cognitive senescence, indicating that post meno-/andropausal changes in HPG axis hormones are implicated in the neuropathology of AD. Studies of transgenic mic...

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Main Authors: Syed Nuruddin, Gry Helen Enger Syverstad, Sveinung Lillehaug, Trygve B Leergaard, Lars N G Nilsson, Erik Ropstad, Anette Krogenæs, Ira Ronit Hebold Haraldsen, Reidun Torp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4121068?pdf=render