Breathing on chip: Dynamic flow and stretch accelerate mucociliary maturation of airway epithelium in vitro

Breathing on chip: Dynamic flow and stretch accelerate mucociliary maturation of airway epithelium in vitro

Human lung function is intricately linked to blood flow and breathing cycles, but it remains unknown how these dynamic cues shape human airway epithelial biology. Here we report a state-of-the-art protocol for studying the effects of dynamic medium and airflow as well as stretch on human primary air...

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Bibliographic Details
Main Authors: Janna C. Nawroth, Doris Roth, Annemarie van Schadewijk, Abilash Ravi, Tengku Ibrahim Maulana, Christiana N. Senger, Sander van Riet, Dennis K. Ninaber, Amy M. de Waal, Dorothea Kraft, Pieter S. Hiemstra, Amy L. Ryan, Anne M. van der Does
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Materials Today Bio
Subjects:
Organs-on-chips
Airway epithelium
Mucociliary clearance
Airflow
Mechanobiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423001734

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http://www.sciencedirect.com/science/article/pii/S2590006423001734

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