Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases

Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases

Abstract Background The interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its effects. Using N-ethyl-N-nitrosourea mutagenesis, we found a mouse with an activating mutation in oligoadenylate synthetase 2...

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Bibliographic Details
Main Authors: Wing-Hong Jonathan Ho, Andrew M. K. Law, Etienne Masle-Farquhar, Lesley E. Castillo, Amanda Mawson, Moira K. O’Bryan, Christopher C. Goodnow, David Gallego-Ortega, Samantha R. Oakes, Christopher J. Ormandy
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Breast Cancer Research
Subjects:
OAS2
Interferon
Immunotherapy
Breast
Mammary
Cancer
Online Access:https://doi.org/10.1186/s13058-022-01525-z

Internet

https://doi.org/10.1186/s13058-022-01525-z

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